Synchronization and Caching Solution for Cost-Effective E-Learning in Resource and Bandwidth Constrained Environments

Electronic learning (e-learning) content delivery and accessibility have received significant research attention over years in order to ensure reliability, availability and cost-effectiveness through Information and Communication Technologies (ICTs).The evolvement of mobile computing devices especially smartphones bring prospects in overcoming the inherent limitations of the Internet when accessing web contents.  Among the potential opportunity revealed includes the ability to work offline. Therefore, this study aims to analyze the existing online and offline e-learning systems in order to explore the uniqueness, technical problems and opportunities in this field. In the same vein, this study proposed synchronization and caching approach for cost-effective e-learning content delivery. The proposed approach synchronizes contents from the original server to local database in mobile computing devices in order to deliver contents to learners in a reliable, cost-effective and timely manner. Finally, comparing existing web-based learning system and the proposed approach, the analyzed results provide empirical evidence that, the proposed approach is significant for bandwidth usage cost saving and hence cost-effectiveness due to ability of working offline. Therefore, synchronization and caching approach cut down several limitations in existing e-learning systems including:  reduction of cost of bandwidth usage; improving system performance by cutting down the servers’ workload and internet usage overheads; cutting down costs of purchasing hardware and increasing motivation in learning activities by allowing learners to access learning contents anywhere and anytime. Keywords: synchronization and caching, e-learning, cost-effectiveness, content delivery, offline

Mobile-based system for cost-effective e-learning contents delivery in resource and bandwidth constrained learning environments

The advancement in Information and Communication Technologies (ICTs) has brought opportunities for the development of Smart Cities. The Smart City uses ICT to enhance performance and wellbeing, to reduce costs and resource consumption, and to engage more effectively and actively with its citizens. In particular, the education sector is adopting new ways of learning in Higher Education Institutions (HEIs) through e-learning systems. While these opportunities exist, e-learning content delivery and accessibility in third world countries like Tanzania is still a challenge due to resource and network constrained environments. The challenges include: high cost of bandwidth connection and usage; high dependency on the Internet; limited mobility and portability features; inaccessibility during the offline period and shortage of ICT facilities. In this paper, we investigate the use of mobile technology to sustainably support education and skills development particularly in developing countries. Specifically, we propose a Cost-effective Mobile Based Learning Content Delivery system for resource and network constrained environments. This system can be applied to cost-effectively broaden and support education in many cities around the world, which are approaching the 'Smart City' concept in their own way, even with less available technology infrastructure. Therefore, the proposed solution has the potential to reduce the cost of the bandwidth usage, and cut down the server workload and the Internet usage overhead by synchronizing learning contents from some remote server to a local database in the user’s device for offline use. It will also improve the quality of experience and participation of learners as well as facilitate mobility and portability in learning activities, which also supports the all-compassing learning experience in a Smart City

First results of phase 3 trial of RTS,S/AS01 malaria vaccine in african children

Background An ongoing phase 3 study of the efficacy, safety, and immunogenicity of candidate malaria vaccine RTS,S/AS01 is being conducted in seven African countries. Methods From March 2009 through January 2011, we enrolled 15,460 children in two age categories - 6 to 12 weeks of age and 5 to 17 months of age - for vaccination with either RTS,S/AS01 or a non-malaria comparator vaccine. The primary end point of the analysis was vaccine efficacy against clinical malaria during the 12 months after vaccination in the first 6000 children 5 to 17 months of age at enrollment who received all three doses of vaccine according to protocol. After 250 children had an episode of severe malaria, we evaluated vaccine efficacy against severe malaria in both age categories. Results In the 14 months after the first dose of vaccine, the incidence of first episodes of clinical malaria in the first 6000 children in the older age category was 0.32 episodes per person-year in the RTS,S/AS01 group and 0.55 episodes per person-year in the control group, for an efficacy of 50.4% (95% confidence interval [CI], 45.8 to 54.6) in the intention-to-treat population and 55.8% (97.5% CI, 50.6 to 60.4) in the per-protocol population. Vaccine efficacy against severe malaria was 45.1% (95% CI, 23.8 to 60.5) in the intention-to-treat population and 47.3% (95% CI, 22.4 to 64.2) in the per-protocol population. Vaccine efficacy against severe malaria in the combined age categories was 34.8% (95% CI, 16.2 to 49.2) in the per-protocol population during an average follow-up of 11 months. Serious adverse events occurred with a similar frequency in the two study groups. Among children in the older age category, the rate of generalized convulsive seizures after RTS,S/AS01 vaccination was 1.04 per 1000 doses (95% CI, 0.62 to 1.64). Conclusions The RTS,S/AS01 vaccine provided protection against both clinical and severe malaria in African children. (Funded by GlaxoSmithKline Biologicals and the PATH Malaria Vaccine Initiative; RTS,S ClinicalTrials.gov number, NCT00866619 .